Relationship Between Gut Microbiota and Intussusception: An Analysis Based on Mendelian Randomization

Abstract

Objective To explore the relationship between intestinal flora and intussusception based on Mendelian randomization.

Methods Genetic data of 211 intestinal microbiota collected by the MiBioGen consortium were used as instrumental variables, and data from a GWAS on intestinal condyloma susceptibility genes from FinnGen were used as outcome variables, which were analyzed by inverse variance weighting (IVW), MR-Egger, Weighted median, Weighted mode, and MR-PRESSO were used to analyze the causal relationship between intestinal flora and intussusception.

Results The inverse variance weighted results showed that Bifidobacterium was inversely associated with the occurrence of intussusception (0R 0.376, 95% CI: 0.157-0.899). In addition, Ruminococcustorques group (0R 1.461, 95% CI: 1.058-3.807), Adlercreutzia (0R 1.893, 95% CI: 1.318-4.502), Allisonella (0R 1.715, 95% CI: 1.009-2.915), and Clostridiumsensustricto1 (0R 1.974, 95% CI: 1.046-4.451) suggested a positive association with the development of intussusception.

Conclusion This two-sample Mendelian randomization study found that Bifidobacterium reduces the risk of intussusception and postoperative recurrent intussusception. Further randomized controlled trials are needed to elucidate the protective effects of probiotics on the development of intussusception and its recurrence, as well as their specific protective mechanisms.