Subjective Global Assessment, Symptoms, Blood Nutritional Indicators and the Associated Factors in Pancreaticobiliary Tumor Patients

Abstract

Abstract: Objective: We aimed to investigate the subjective global assessment (SGA), symptoms and blood nutritional indicators in pancreaticobiliary tumor patients and the associated factors. Method: 153 pancreaticobiliary tumor patients’information was collected on admission including SGA, symptoms, blood lymphocyte count (Lmy), hemoglobin (Hb), creatinine (Cr), total cholesterol (TC), total triacylglycerol (TG), serum C-reactive protein (CRP), globulin, albumin (Alb), prealbumin (PA), transferrin (Tf), retinol binding protein (RBP) and micro-nutrients (folic acid, vit B12, vit A, vit E, vit K, vit D, iron, zinc and copper). Associated factors were explored. Result:  Advanced tumor stage, elevated CRP and CA 19-9 were risk factors for malnutrition by SGA; elevated CRP contributed to fatigue, anorexia and pain; Alb, PA and Tf decreased with age; advanced tumor stage was associated with elevated vit B12;elevated CRP was associated with decreased Hb, Alb, PA, Tf, RBP, vit A, vit D and increased globulin and copper; SGA was associated with decreased Lym, HB, Alb, PA and Tf; elevated bilirubin was associated with decreased Cr , Alb, vit K and vit D, and increased TC, TG, vit B12 and copper; Conclusion： Inflammation should be controlled to relieve the discomforts; old patients should give more protein; advanced cancer underestimates vitB12 deficiency. Inflammation overestimates the deficiency of serum protein, vit A, vit D, iron and zinc. Malnutrition by SGA increases the deficiency of Lym and serum protein. Obstructive jaundice increases the deficiency of Cr, Alb, vit D and vitK, and cause vitB12 elevation, hyperlipemia, and copper accumulation.