The Causal Effects of Appendicectomy on Immune Bowel Disease and Digestive Cancers: A Two-sample Mendelian Randomization Study

Authors

  • Junyu Huang Department of Gastroenterology, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, China
  • Zan Liu * Department of Health management center, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, China

Keywords:

appendicectomy, immune bowel disease, digestive cancers, mendelian randomization, causality

Abstract

Background: Previous observational studies have reported that appendicectomy is associated with IBD and digestive cancers. Using a two-sample mendelian randomization (MR) analysis, we aimed to investigate whether appendicectomy is causally associated with IBD and digestive cancers.

Methods: The instrumental variables (IVs) were obtained from public genome-wide association studies (GWAS) data. We used the inverse-variance weighted (IVW) method as the primary statistical method complemented with weighted median and MR-Egger approaches.

Results: The IVW method revealed that genetically determined appendicectomy had a causal effect on pancreatic cancer(OR 202.61; 95% CI 1.39, 29563.10; P = 0.037), but did not have causal effects on  IBD (P > 0.05) and other digestive cancers (P > 0.05).

Conclusion: This study revealed that genetically determined appendicectomy had a causal effect on pancreatic cancer and patients with appendectomy should be screened for pancreatic cancer.

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Published

2024-08-31

Issue

Vol. 94 No. 4 (2024): Volume 94, Issue 4

Section

Original Articles

How to Cite

Junyu Huang, and Zan Liu * , trans. 2024. “The Causal Effects of Appendicectomy on Immune Bowel Disease and Digestive Cancers: A Two-Sample Mendelian Randomization Study”. Human Biology 94 (4): 769-73. https://www.humbiol.org/Home/article/view/167.

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